Closely observed pains.

Closely observed pains.

Outside the groves of academe few people today read George Crabbe's trenchant rhymed couplets describing the life and landscape of his native Suffolk in the late eighteenth and early nineteenth centuries. This is a pity because Crabbe is a real original: an unpoetical poet who believed that it was his duty to instruct his readers as accurately as possible about the painful realities ofhuman lif...

Growing Pains

CONTEXT The term growing pains describes a common, benign syndrome of recurrent discomfort that occurs in young children. First described in the 1800s, the etiology of this condition remains unclear. The peak incidence does not correspond to a time of rapid growth. Children typically report bilateral pain in the lower extremities that occurs late in the day or at night. EVIDENCE ACQUISITION T...

Orofacial Pains

1Department of Cognitive Neuroscience, Institute for Cognitive Science Studies, Tehran, Iran 2Department of Dental Anatomy, Faculty of Dentistry, Islamic Azad University, Tehran, Iran 3Programme in Experimental Medicine and Therapy, Doctoral School in Life and Health Sciences, Maxillofacial Surgery Section, Surgical Sciences Department, S. Giovanni Battista Hospital, University of Turin, Turin,...

Growing pains.

Growing pains.

Background: MeCP2, methyl-CpG-binding protein 2, binds to methylated cytosines at CpG dinucleotides, as well as to unmethylated DNA, and affects chromatin condensation. MECP2 mutations in females lead to Rett syndrome, a neurological disorder characterized by developmental stagnation and regression, loss of purposeful hand movements and speech, stereotypic hand movements, deceleration of brain ...